Charles A Kunos Selected Research

Electrolytes

1/2019	Randomized Phase II Trial of Triapine-Cisplatin-Radiotherapy for Locally Advanced Stage Uterine Cervix or Vaginal Cancers.
1/2017	Phase I Trial of Triapine-Cisplatin-Paclitaxel Chemotherapy for Advanced Stage or Metastatic Solid Tumor Cancers.
1/2017	Phase I trial of daily triapine in combination with cisplatin chemotherapy for advanced-stage malignancies.
7/2013	Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers.

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Charles A Kunos Research Topics

Disease

45	Neoplasms (Cancer) 01/2021 - 12/2009
12	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2021 - 02/2010
6	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 02/2011
5	Fatigue 01/2019 - 02/2011
4	Thrombocytopenia (Thrombopenia) 01/2021 - 02/2011
3	Prostatic Neoplasms (Prostate Cancer) 04/2022 - 01/2004
3	Vaginal Neoplasms (Cancer, Vaginal) 01/2019 - 01/2012
3	Leukopenia 01/2019 - 01/2017
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 01/2020
2	Neutropenia 01/2021 - 01/2019
2	Carcinoma (Carcinomatosis) 09/2020 - 11/2018
2	Methemoglobinemia 01/2019 - 02/2012
2	Dyspnea (Shortness of Breath) 01/2017 - 02/2012
2	Diarrhea 07/2013 - 02/2011
2	Endometrial Neoplasms (Endometrial Cancer) 12/2011 - 07/2011
2	Sarcoma (Soft Tissue Sarcoma) 02/2010 - 01/2008
1	Neoplasm Metastasis (Metastasis) 04/2022
1	Pain (Aches) 04/2022
1	Disease Progression 01/2021
1	Medulloblastoma 01/2020
1	Brain Neoplasms (Brain Tumor) 01/2020
1	Bone Fractures (Bone Fracture) 01/2020
1	Ataxia Telangiectasia (Louis Bar Syndrome) 09/2019
1	Leukemia 01/2019
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2019
1	Thyroid Neoplasms (Thyroid Cancer) 05/2018
1	Glioblastoma (Glioblastoma Multiforme) 09/2017
1	Anemia 01/2017
1	Vulvar Neoplasms (Vulvar Cancer) 01/2017
1	Colonic Neoplasms (Colon Cancer) 09/2015
1	Rectovaginal Fistula 01/2015
1	Nausea 07/2013
1	Pancreatic Neoplasms (Pancreatic Cancer) 04/2013
1	Headache (Headaches) 02/2012
1	Adenocarcinoma 12/2011
1	Ovarian Epithelial Carcinoma 02/2011
1	Epistaxis (Nosebleed) 02/2011
1	Febrile Neutropenia 02/2011

Drug/Important Bio-Agent (IBA)

14	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 09/2019 - 12/2009
11	3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA 11/2020 - 12/2009
10	RadiopharmaceuticalsIBA 04/2022 - 05/2018
9	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 02/2010
7	DeoxyribonucleotidesIBA 01/2019 - 12/2009
4	ElectrolytesIBA 01/2019 - 07/2013
3	Radioisotopes (Radionuclides)IBA 04/2022 - 01/2019
3	PlatinumIBA 01/2022 - 09/2020
3	Gemcitabine FDA Link 01/2021 - 01/2015
3	AntigensIBA 01/2021 - 04/2014
3	Drug CombinationsIBA 01/2019 - 01/2019
3	Carboplatin (JM8)FDA LinkGeneric 11/2018 - 01/2015
2	Pharmaceutical PreparationsIBA 09/2020 - 09/2017
2	Angiogenesis InhibitorsIBA 09/2019 - 04/2014
2	DNA (Deoxyribonucleic Acid)IBA 09/2019 - 01/2012
2	Biological ProductsIBA 01/2019 - 04/2014
2	Paclitaxel (Taxol)FDA LinkGeneric 11/2018 - 01/2017
2	Oxygen (Dioxygen)IBA 04/2014 - 02/2012
2	Proteins (Proteins, Gene)FDA Link 11/2010 - 12/2009
1	Testosterone (Sustanon)FDA Link 04/2022
1	Radium-223IBA 04/2022
1	Pentetic Acid (DTPA)FDA LinkGeneric 04/2022
1	Pemetrexed (MTA)FDA Link 01/2022
1	adavosertibIBA 01/2021
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2021
1	Tenofovir (Viread)FDA Link 11/2020
1	Emtricitabine (Emtriva)FDA Link 11/2020
1	AndrogensIBA 01/2020
1	VaccinesIBA 01/2020
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2020
1	Cancer VaccinesIBA 01/2020
1	CyclinsIBA 09/2019
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 09/2019
1	Investigational DrugsIBA 09/2019
1	Protein Kinases (Protein Kinase)IBA 09/2019
1	Phosphotransferases (Kinase)IBA 09/2019
1	human ERBB2 proteinIBA 01/2019
1	A-Form DNA (A-DNA)IBA 01/2019
1	Therapeutic UsesIBA 01/2019
1	Immune Checkpoint InhibitorsIBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2014
1	Antineoplastic Agents (Antineoplastics)IBA 04/2014
1	cabazitaxel FDA Link 01/2013
1	AntidotesIBA 02/2012
1	Methylene Blue (Methylthioninium Chloride)FDA Link 02/2012
1	Deoxyglucose (2 Deoxy D glucose)IBA 12/2011
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 12/2011
1	triphosphoric acid (triphosphate)IBA 12/2011
1	Docetaxel (Taxotere)FDA Link 02/2011

Therapy/Procedure

22	Therapeutics 04/2022 - 09/2012
14	Drug Therapy (Chemotherapy) 01/2019 - 02/2011
12	Radiotherapy 01/2021 - 01/2008
9	Chemoradiotherapy 01/2021 - 01/2012
5	Brachytherapy 01/2019 - 01/2004
3	Palliative Care (Palliative Therapy) 01/2021 - 01/2015
2	Immunotherapy 01/2020 - 01/2018
1	Precision Medicine 04/2022
1	Gamma Cameras (Gamma Camera) 04/2022
1	Castration 04/2022
1	Investigational Therapies (Experimental Therapy) 01/2020
1	Aftercare (After-Treatment) 01/2019
1	Adjuvant Chemotherapy 12/2011